AB0345 ACPA TITER IS AN INDEPENDENT DETERMINANT OF SERUM CTX IN PATIENTS WITH ACTIVE RHEUMATOID ARTHRITIS

Background Serum C-terminal telopeptide of type I collagen (CTX - a marker bone resorption) and ACPA titer have been associated to higher erosive score in rheumatoid arthritis (RA) lower mineral density (BMD), even patients with pre-arthritis. Prominent inflammatory status cannot totally explain such association. The interplay between ACPA, disease activity, BMD CTX is still unclear. Objectives To investigate the determinants serum levels RA patients. Methods We conducted cross-sectional analysis on active activity failure first-line cDMARDs candidate bDMARDs. Clinical, laboratoristic densitometric parameters were collected. CTX, Procollagen Intact N-Terminal Peptide (P1NP), Dkk1, Sclerostin (SOST), 25-OH-Vitamin D (VitD), PTH, RANKL, OPG, B-ALP dosed. Potential predictors analyzed using hierarchical regressions. selected based screened via simple regression analyses which included single baseline predictor each model. Any p < 0.10 entered multivariable model (model 1). also linear forcing variables from literature 2). Results GraphPad Prism version 9.5.0 for Windows, Software, San Diego, California USA. enrolled 62 study. DAS28-CRP at was 4.17 (SD 1.28). 80.6% positive. factors univariate were: titer, DAS28-CRP, B-ALP, P1nP ( table 1 ). only independent factor significantly both 2 Univariate Model (fully adjusted) Variable Estimate SD P value 4,815e-005 1,299e-005 0,0005 3,602e-005 1,344e-005 0,01 4,730e-005 1,497e-005 0,003 Age 0,001 0,34 -0,0004 0,69 GC daily dose 0,002 0,46 0,009 0,09 0,18 0,02 0,11 RF 0,0001 0,0002 0,51 0,006 0,005 0,37 0,004 0,0006 0,40 -0,0001 0,87 Dkk1 9,143e-005 0,0008 0,91 -0,0009 0,0007 0,20 SOST -0,0003 0,73 RANKL/OPG ratio -0,30 0,47 0,53 PTH 0,86 0,61 VitD 0,44 -0,0008 Neck (g/cm2 ) -0,24 0,03 -0,1531 0,1001 0,13 -0,23 0,06 Conclusion found that an determinant activity. REFERENCES: NIL. Acknowledgements: Disclosure Interests Giovanni Adami Speakers bureau: Eli-Lilly, Theramex, Galapagos, UCB, Amgen, BMS, Fresenius Kabi, Orsolini: None declared, Angelo Fassio: Davide Bertelle: Camilla Benini: Ombretta Viapiana: Gatti: Maurizio Rossini: declared.